Tramadol is a pain reliever that is used to treat moderate to moderately severe pain in adults. The oral intake of Tramadol immediate-release formulation, the onset of pain relief usually begins within an hour. Tramadol was patented in 1963 and was first launched in 1977 by some Pharmaceutical Company of erstwhile West Germany. Latter was introduced in the UK and the USA. Tramadol was introduced in India in the late '90s was categories as schedule H1 drug as per the Drug and Cosmetic Act, 1940. Therefore, Tramadol can only be used through prescription. You may buy Tramadol online but only against prescription.
Chemically Tramadol is 2-(dimethyl aminomethyl)-1-(3-methoxyphenyl) cyclohexanol is a centrally acting analgesic in action. Tramadol has the multidimensional mode of action as in one side enantiomer act on the serotonin and noradrenaline reuptake, and on the other hand, the O-desmethyl metabolite acts on the µ-opioid receptor, producing analgesic action includes both non-opioid components. At the same time, the enantiomer of Tramadol contributes to analgesia by inhibiting the reuptake of serotonin, by inhibiting the reuptake of noradrenaline, and the O-desmethyl metabolite by binding with relatively high affinity to the µ-opioid receptor.
After oral intake or intramuscular/ intravenous administration, Tramadol is almost completely absorbed more than 90%, with an average bioavailability of 70%, irrespective of current food intake. Peak blood serum level reaches within 1-2 hours after oral intake and sustained up to 6 hours, and 45 minutes after intramuscular/ intravenous administration, and sustained up to 6 hours.
Oral intake and intramuscular/ intravenous administration, Tramadol does not differ significantly between adults and children.
The oral intake of Tramadol 90% is eliminated through urine, and 10% through feces. Out of 90% excretion through urine, 30% excreted unchanged, and 60% in the form of free and conjugated metabolites.
Tramadol is mainly used to relieve pain or chronic pain.
Tramadol for Adult and Children in the case of pain is referred for 50 to 100 mg four times daily with a maximum of 400mg in a day both orally and injectable. Titration of the dosage is suggested as per the severity of the pain. In the case of chronic pain, it is referred 100 mg once daily can be gradually increased after every 5 days with a maximum of 300mg a day. You can buy Tramadol 50 mg cash on delivery.